Effect of Cionin on Histamine and Acid Secretion by the Perfused Rat Stomach

R. Mårvik Section of Gastroenterology, Dept. of Surgery, and Department of Medicine, Trondheim University Hospital, Trondheim, Norway; Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

A. H. Johnsen Section of Gastroenterology, Dept. of Surgery, and Department of Medicine, Trondheim University Hospital, Trondheim, Norway; Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

J. F. Rehfeld Section of Gastroenterology, Dept. of Surgery, and Department of Medicine, Trondheim University Hospital, Trondheim, Norway; Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

A. Sandvik Section of Gastroenterology, Dept. of Surgery, and Department of Medicine, Trondheim University Hospital, Trondheim, Norway; Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

H. L. Waldum Section of Gastroenterology, Dept. of Surgery, and Department of Medicine, Trondheim University Hospital, Trondheim, Norway; Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Abstract

Mårvik R, Johnsen AH, Rehfeld JF, Sandvik A, Waldum HL. Effect of cionin on histamine and acid secretion by the perfused rat stomach. Scand J Gastroenterol 1994;29:591-594

Background: The protochordean octapeptide cionin is structurally a hybrid of mammalian chole-cystokinin (CCK) and gastrin. An earlier study has shown that cionin in mammals stimulates gallbladder contraction and gastric somatostatin release, similarly to CCK-8.

Methods: In the present study we examined the effect of cionin on histamine release and acid secretion of the stomach, both effects being mediated by CCK-B/gastrin receptors.

Results: Cionin induced a concentration-dependent increase in histamine release and acid secretion in the isolated, vascularly perfused rat stomach, detectable at a concentration of 4 pM and reaching a maximum at a concentration of 512 pM. The CCK-B/gastrin receptor antagonist L 365,260 abolished the stimulating effect of cionin on both histamine release and acid secretion, whereas the CCK-A receptor antagonist L 364,718 only had a faint effect.

Conclusion: Cionin is a potent and efficient stimulator of gastric histamine release and acid secretion interacting via a CCK-B receptor.

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Effect of Cionin on Histamine and Acid Secretion by the Perfused Rat Stomach

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Effect of Cionin on Histamine and Acid Secretion by the Perfused Rat Stomach

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