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Original Article

Endoscopic Ultrasonographic Evaluation of Gastric Ulcer Healing on Treatment with Proton Pump Inhibitors versus H2-Receptor Antagonists

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Pages 1140-1144 | Received 10 Jan 1994, Accepted 05 Apr 1994, Published online: 08 Jul 2009
 

Abstract

Tanaka M, Maruoka A. Chijiiwa Y, Tanaka M, Nawata H. Endoscopic ultrasonographic evaluation of gastric ulcer healing on treatment with proton pump inhibitors versus H2-receptor antagonists. Scand J Gastroenterol 1994;29:1140-1144.

Background: It has been reported that time to peptic ulcer healing is shorter with proton pump inhibitors (PPI) than with H2-receptor antagonists (H2-RA). This study was designed to examine the difference in the healing process between gastric ulcers treated with PPI and those treated with H2-RA.

Methods: The healing of deep gastric ulcers treated with PPI (n = 11) or H2-RA (n = 13) was evaluated with endoscopic ultrasonography (EUS). Every 2 weeks during treatment EUS variables such as the width and the depth of the ulcer crater, the thickness and size of the low echoic area of the ulcer base, and the distance of the disrupted muscularis propria were measured. The contraction rates of EUS variables, the ratios of the contraction rate of the depth to that of the width of the ulcer crater (D/W ratio) and the contraction rate of the distance of the disrupted muscularis propria layer to that of the width of the ulcer crater (Dm/W ratio) were calculated.

Results: Only at week 2 were the D/W ratio and Dm/W ratio significantly higher in the group receiving PPI (D/W ratio, 1.79 ±0.701; Dm/W ratio, 0.938 ±0.207) than in the group receiving H2-RA (D/W ratio, 1.10 + 0.559; Dm/W ratio, 0.641 ±0.166).

Conclusion: This study demonstrated that PPI therapy is associated with more rapid and stronger healing than obtained with H2-RA during the early treatment period.

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