5
Views
9
CrossRef citations to date
0
Altmetric
Original Article

DNA Aneuploidy in Gastric Carcinoma Flow Cytometric Data Related to Survival, Location, and Histopathologic Findings

, , , &
Pages 258-264 | Received 07 Mar 1994, Accepted 23 Jun 1994, Published online: 08 Jul 2009
 

Abstract

Background: The aim of the study was to evaluate the prognostic significance of DNA ploidy of gastric carcinomas. Methods: The DNA content was analyzed by flow cytometry on archival paraffin-embedded material from tumors of 97 consecutive patients. Results: A multivariate analysis showed that the DNA ploidy pattern and lymph node metastasis were the only independent prognostic markers for survival (p = 0.01 and p = 0.02, respectively). The relative risk of death due to gastric cancer was three times greater for patients with DNA hypertetraploid tumors than for patients with DNA diploid tumors and twice as high for patients with lymph node metastasis as for patients without. Well and moderately differentiated carcinomas were more frequently aneuploid than tumors with poor differentiation (p = 0.047). There was no correlation between tumor ploidy pattern and location. In univariate analysis tumor growth through the serosal wall was predictive of poor survival (p = 0.003). Conclusions: DNA ploidy is an independent prognostic indicator for cancer-specific survival in gastric cancer.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.