Serum Trypsinogen-2 in the Prediction of Outcome in Acute Necrotizing Pancreatitis

V. Sainio Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

P. Puolakkainen Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

E. Kemppainen Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

J. Hedström Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

R. Haapiainen Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

L. Kivisaari Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

U.-H. Stenman Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

T. Schröder Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

E. Kivilaakso Dept. II of Surgery, Dept. of Radiology, and Dept. of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland

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Abstract

Background: The accuracy of serum trypsinogen-2 in predicting the severity of acute necrotizing pancreatitis (ANP) was prospectively evaluated in 52 consecutive patients. Methods: A new sensitive immunofluorometric assay was used for serum trypsinogen-2. Results: Mean values during the first 24 h were 42.1 μg/l in control patients, 1435 μg/l in uncomplicated cases, and 4090 μg/l in complicated or fatal cases. There was a significant difference in serum trypsinogen-2 values between patients with uncomplicated and complicated disease (p = 0.002) already on admission. When a cutoff level of 1000 μg/l was used, patients with uncomplicated ANP were differentiated from patients with complicated ANP with a sensitivity of 91% and with a specificity of 71%. Conclusions: The immunofluorometric assay of serum trypsinogen-2 is a sensitive and specific method for prediction of the severity of the disease in necrotizing pancreatitis.

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Serum Trypsinogen-2 in the Prediction of Outcome in Acute Necrotizing Pancreatitis

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Serum Trypsinogen-2 in the Prediction of Outcome in Acute Necrotizing Pancreatitis

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