Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

K. Sjölund Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

R. Ekman Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

S. Lindgren Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

J. F. Rehfeld Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

Abstract

Background: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex. Methods: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal. Results: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients. Conclusions: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

Related Research Data

Information for

Open access

Opportunities

Help and information

Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related Research Data

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature