Treatment of Helicobacter pylori Infection by Topical Administration of Antimicrobial Agents

Abstract

A technique has been developed in which a combination of bismuth subnitrate, amoxycillin and metronidazole is instilled into the stomach via a nasogastric tube and removed after 1 hour, thereby avoiding the side-effects often seen with triple therapy. This technique has achieved eradication of H. pylori in 24 of 25 patients with non-ulcer dyspepsia. A modified version of the technique was used in six patients, and eradication achieved in each case.

Key Words:

• Amoxycillin
• antibiotics
• bismuth
• endoscopy
• Helicobacter pylori
• metronidazole
• topical administration