Colorectal Dysplasia and Carcinoma in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis

M. H. K. Leidenius Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

M. A. Färkkila Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

P. Kärkkäinen Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

E. I. Taskinen Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

I. H. Kellokumpu Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

K. A. V. Höckerstedt Fourth Dept. of Surgery, Dept. of Medicine, and Dept. of Pathology and Transplantation Pathology, Helsinki University Central Hospital, Helsinki, Finland

Abstract

Background: The aim of this study was to evaluate the role of primary sclerosing cholangitis (PSC) as a cofactor in the dysplasia-carcinoma sequence in ulcerative colitis (UC). Methods: Forty-five patients with UC and concomitant PSC and 45 pair-matched control patients with UC only were examined for colorectal dysplasia and carcinoma. Results: The median duration of UC was 11 years in the group with UC and PSC and 15 years in the control group. Thirteen of the 45 patients (29%) with UC and PSC had colorectal neoplasia: 4, carcinoma; 2, high-grade dysplasia; and 7, low-grade dysplasia. Four of the 45 control patients (9%) had neoplastic findings: 1, carcinoma; 1, high-grade dysplasia, and 2, low-grade dysplasia (P < 0.05). Conclusion: The results suggest that the risk of colorectal dysplasia and carcinoma in patients with UC is increased by concomitant PSC.

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Colorectal Dysplasia and Carcinoma in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis

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Colorectal Dysplasia and Carcinoma in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis

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