Focal Inflammatory Infiltrations in Gastric Biopsy Specimens Are Suggestive of Crohn's Disease

A. Meining Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

E. Bayerdörffer Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

E. Bästlein Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

N. Raudis Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

C. Thiede Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

B. Cyrus Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

W. Krämer Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

H. Klann Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

J. Labenz Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

M. Stolte Dept. of Internal Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany; Dept. of Gastroenterology, Hepatology & Infectious Diseases, University of Magdeburg, Magdeburg, Germany; Department of Haematology and Oncology, Rudolf Virchow Klinikum, Free University Berlin, Berlin, Germany; Dept. of Medicine, Elisabeth Hospital, Essen, Germany; Dept. of Pathology, Klinikum Bayreuth, Bayreuth, Germany; Private Practice, Pirmasens, Passau, Munich, Germany

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Abstract

Background: Crohn's disease is a systemic inflammatory disease that may involve all regions of the gut. Methods: Thirty-six patients with Crohn's disease and 36 age- and sex-matched control patients were prospectively evaluated by upper endoscopy. Biopsy specimens were taken from the oesophagus, duodenum, and 10 locations in the antrum and corpus. Results: Granulomas were found in four patients (11.13%) with Crohn's disease but in none of the control patients (P ±0.5). In 23 of 36 patients (63.9%) with Crohn's disease focal inflammatory infiltrations were found, as compared with 7 of 36 (19.4%) of the controls (P < 0.001). For focal inflammatory infiltrations, an odds ratio of 7.33 (2.55–21.38) was calculated, which increased to 20.04 (4.07–98.45) when only specimens from the angulus were considered. Helicobacter pylori infection was present in 13 of 36 controls (36.1%) and in 3 of 36 patients (8.3%) with Crohn's disease (P = 0.009). Conclusion: These data suggest that Crohn's disease is typically associated with focal inflammatory infiltrations of the gastric mucosa.

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Focal Inflammatory Infiltrations in Gastric Biopsy Specimens Are Suggestive of Crohn's Disease

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