The Growth of Primary Low-Grade B-Cell Gastric Lymphoma Is Sustained by Helicobacter pylori

G. Cammarota Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

A. Tursi Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

A. Papa Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

M. T. Voso Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

F. Serra Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

P. Chiusolo Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

G. Fedeli Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

G. Gasbarrini Catholic University, Dept. of Internal Medicine, Division of Gastroenterology, Dept. of Hematology, Institute of Pathology, Policlinico ‘A. Gemelli', Rome, Italy

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Abstract

Background: The growth of primary low-grade B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an antigen-dependent process. Case: We were able to document the influence of Helicobacter pylori on the natural history of primary low-grade B-cell gastric MALT lymphoma in a case investigated by means of polymerase chain reaction for IgH rearrangement. In this case the presence or absence of the bacterium appeared to affect both clinical manifestations and histologic features of the neoplasia, with an acceleration or a slowing down of the neoplastic expansion, respectively. Conclusions: We identified H. pylori as an antigenic stimulus that supports the growth of MALT-type lymphoma. This finding enables us to make some considerations about the management of the disease.

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The Growth of Primary Low-Grade B-Cell Gastric Lymphoma Is Sustained by Helicobacter pylori

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The Growth of Primary Low-Grade B-Cell Gastric Lymphoma Is Sustained by Helicobacter pylori

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