40
Views
37
CrossRef citations to date
0
Altmetric
Original Article

Large-Scale Ambulatory Study of Postprandial Jejunal Motility in Irritable Bowel Syndrome

, , , &
Pages 39-47 | Received 29 May 1996, Accepted 14 Aug 1996, Published online: 08 Jul 2009
 

Abstract

Background: The relationship of small-bowel dysmotility to dietary intake in irritable bowel syndrome (IBS) is obscure. Methods: This study evaluated postprandial jejunal motility in IBS patients classified as constipation-predominant (n=25) or diarrhoea-predominant (n=35) and compared results against 18 volunteers. Twenty-four-hour ambulatory jejunal manometry was carried out in all subjects, and recordings were analysed by microcomputer and visual assessment. Results: By means of analysis of variance (fitting factors for channels, meals, and time periods) postprandial contraction frequency was greater in both patient groups compared with normal (constipation-predominant versus normal, diarrhoea-predominant versus normal; P < 0.001). In the constipation-predominant cohort, contraction amplitudes were lower (constipation-predominant versus normal; P < 0.002). Discrete cluster contractions occurred with similar frequency and duration in both patient and volunteer groups. Conclusions: Quantitative differences of postprandial jejunal contraction characteristics have been shown between patients with IBS and healthy volunteers. Contraction frequency is greater than normal in both diarrhoea-and constipation-predominant categories, whereas contraction amplitudes are lower in constipation-predominant patients.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.