Helicobacter pylori Infection Accelerates Gene Expression of Glicentin in the Gastric Mucosa: Its Association with Intestinal Metaplasia of the Stomach

S. Ishihara Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

R. Fukuda Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

N. Moriyama Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

N. Ishimura Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

T. Kaji Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

Y. Kushiyama Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

K. Amano Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

K. Hirakawa Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

Y. Amano Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

K. Adachi Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

N. Ashizawa Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

S. Fukumoto Second Dept. of Internal Medicine, Shimane Medical University, Shimane, Japan

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Abstract

Background: Glicentin is an intestinal polypeptide hormone which seems to promote intestinal metaplasia (IM) in the gastric mucosa. The aim of this study was to clarify whether Helicobacter pylori infection accelerates glicentin gene expression. Method: Glicentin mRNA was investigated by reverse-transcription polymerase chain reaction using gastric biopsies from 47 patients examined endoscopieally and denying IM. Results: IM was observed in 18 (38.3%) cases histologically, but not in the other 29 (62.7%). Glicentin mRNA was significantly correlated with histological IM (P < 0.01) and was positively correlated with H. pylori infection (P < 0.05). Conclusion: Our results indicate that H. pylori infection is associated with the induction of glicentin in the gastric mucosa, thus supporting the hypothesis that H. pylori infection accelerates IM of the stomach.

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Helicobacter pylori Infection Accelerates Gene Expression of Glicentin in the Gastric Mucosa: Its Association with Intestinal Metaplasia of the Stomach

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Helicobacter pylori Infection Accelerates Gene Expression of Glicentin in the Gastric Mucosa: Its Association with Intestinal Metaplasia of the Stomach

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