Reversal of Long-Standing Iron Deficiency Anaemia after Eradication of Helicobacter pylori Infection

M. Marignani 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

S. Angeletti 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

C. Bordi 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

F. Malagnino 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

C. Mancino 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

G. Delle Fave 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

B. Annibale 1st Dept. of Gastroenterology, Institute of Haematology, La Sapienza University, Rome, Italy; Institute of Histology and Pathologic Anatomy, University of Parma, Parma, Italy

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Abstract

Helicobacter pylori has been proposed as a major determinant in multiple gastric disorders. We describe the case of a young adult with a long-standing medical history of sideropenic anaemia and of oral iron consumption dependence with a chronic superficial H. pylori-positive gastritis. All other causes of sideropenic anaemia were carefully excluded. Histology showed a peculiar pattern of non-active H. pylori-positive gastritis. The bacterium was a non-VacA-producing strain. The first attempt at eradication caused a reduction in bacterial load and led to a partial normalization of haematologic variables without improving the ferritin level. A successful second course of eradication therapy completely reversed the anaemia and restored the iron deposit, which persisted at the 29-month follow-up. H. pylori infection can be involved in unexplained cases of iron deficiency anaemia in adults, and its cure can normalize the haematologic picture.

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Reversal of Long-Standing Iron Deficiency Anaemia after Eradication of Helicobacter pylori Infection

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Reversal of Long-Standing Iron Deficiency Anaemia after Eradication of Helicobacter pylori Infection

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