Monobactam and aminoglycoside combination therapy against metallo-β-lactamase-producing multidrug-resistant Pseudomonas aeruginosa screened using a ‘break-point checkerboard plate’

Hideki Araoka Department of Infectious DiseasesCorrespondence[email protected]

Masaru Baba Department of Infectious Diseases

Shinsuke Takagi Department of Haematology, Toranomon Hospital, Tokyo, Japan

Naofumi Matsuno Department of Haematology, Toranomon Hospital, Tokyo, Japan

Kazuya Ishiwata Department of Haematology, Toranomon Hospital, Tokyo, Japan

Nobuaki Nakano Department of Haematology, Toranomon Hospital, Tokyo, Japan

Masanori Tsuji Department of Haematology, Toranomon Hospital, Tokyo, Japan

Hisashi Yamamoto Department of Haematology, Toranomon Hospital, Tokyo, Japan

Sachiko Seo Department of Haematology, Toranomon Hospital, Tokyo, Japan

Yuki Asano-Mori Department of Haematology, Toranomon Hospital, Tokyo, Japan

Naoyuki Uchida Department of Haematology, Toranomon Hospital, Tokyo, Japan

Kazuhiro Masuoka Department of Haematology, Toranomon Hospital, Tokyo, Japan

Atsushi Wake Department of Haematology, Toranomon Hospital, Tokyo, Japan

Shuichi Taniguchi Department of Haematology, Toranomon Hospital, Tokyo, Japan

Akiko Yoneyama Department of Infectious Diseases

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Abstract

Metallo-β-lactamase-producing multidrug-resistant Pseudomonas aeruginosa (MDR P. aeruginosa) is a cause of life-threatening infections. With parenteral colistin not available in Japan, we treated MDR P. aeruginosa sepsis with monobactam and aminoglycoside combination therapy, with screening using a ‘break-point checkerboard plate’.

Declaration of interest: There is no conflict to declare.

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Monobactam and aminoglycoside combination therapy against metallo-β-lactamase-producing multidrug-resistant Pseudomonas aeruginosa screened using a ‘break-point checkerboard plate’

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Monobactam and aminoglycoside combination therapy against metallo-β-lactamase-producing multidrug-resistant Pseudomonas aeruginosa screened using a ‘break-point checkerboard plate’

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