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Abstract
We report 3 cases of disease – leptospirosis, tropical malaria and fulminant meningococcaemia – associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability. Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.
Acknowledgements
The study was supported by grant IGA NR/9316-3 from the Ministry of Health of the Czech Republic and by grant MSM 0021620806 from the Ministry of Youth, Education and Sports of the Czech Republic.
Declaration of interest: Hansa Medical (Lund, Sweden) has filed patent applications on HBP as a diagnostic target, and HH is listed as one of the inventors. The application is pending. The remaining authors declare no competing financial interests.
