Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

Yoichi HirakiDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, KumamotoCorrespondence[email protected]

Mikako HiraikeDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto

Masahisa NaganoDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto

Yukari OzonoDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto

Kenichi ManabeDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto

Nobuhiro MisumiDepartment of Pharmacy, National Hospital Organization Kyushu Medical Center, Fukuoka City, Fukuoka

Yasuhiro TsujiDepartment of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki

Hidetoshi KamimuraDepartment of Pharmaceutical and Health Care Management, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka

Yoshiharu KarubeLaboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

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Abstract

We investigated the pharmacokinetics of gentamicin in a haemodialysis patient treated for endocarditis caused by methicillin-resistant Staphylococcus aureus and found that the administration of gentamicin immediately prior to dialysis was a suitable strategy for reaching target maximum drug concentration (Cmax) values and low trough levels.

Keywords::

Declaration of interest: Funding was provided by institutional sources only. None of the authors have any conflicts of interest to declare.

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Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

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Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis

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