Cerebrospinal fluid penetration of tigecycline

Carlo PallottoFrom the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, “Santa Maria della Misericordia” Hospital, PerugiaCorrespondence[email protected]

Maurizio FiorioFrom the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, “Santa Maria della Misericordia” Hospital, Perugia

Antonio D’AvolioUnit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy

Alessio SgrelliFrom the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, “Santa Maria della Misericordia” Hospital, Perugia

Franco BaldelliFrom the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, “Santa Maria della Misericordia” Hospital, Perugia

Giovanni Di PerriUnit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy

Giuseppe Vittorio De SocioFrom the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, “Santa Maria della Misericordia” Hospital, Perugia

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Abstract

We report, in a clinical setting, the tigecycline concentration and area under the concentration–time curve (AUC) – both in blood and in cerebrospinal fluid (CSF) – of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC_0–12 ratio was 0.067.

Keywords::

Declaration of interest: No conflict of interest.

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Cerebrospinal fluid penetration of tigecycline

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Cerebrospinal fluid penetration of tigecycline

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