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Abstract
We report, in a clinical setting, the tigecycline concentration and area under the concentration–time curve (AUC) – both in blood and in cerebrospinal fluid (CSF) – of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC0–12 ratio was 0.067.
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Declaration of interest: No conflict of interest.