155
Views
5
CrossRef citations to date
0
Altmetric
SHORT COMMUNICATIONS

Prevalence and characteristics of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated from pediatric inpatients with respiratory tract infections at a teaching hospital in China

, , , &
Pages 200-203 | Received 11 Sep 2013, Accepted 18 Oct 2013, Published online: 20 Dec 2013
 

Abstract

The aim of this study was to investigate the prevalence and characteristics of resistant Klebsiella pneumoniae isolates in the pediatric setting in China. A total of 201 non-duplicate K. pneumoniae isolates were obtained from 432 pediatric inpatients suffering from respiratory tract infections. One hundred and thirty-eight K. pneumoniae isolates were determined to be extended-spectrum beta-lactamase-producers. Of all ESBL-producing isolates, 138 (100%) were resistant to piperacillin, ampicillin, cefazolin, and aztreonam, 136 (98.4%) to cefuroxime, 126 (91.2%) to ceftriaxone and co-trimoxazole, 120 (87.4%) to cefoperazone, 91 (65.8%) to ceftazidime, 78 (56.5%) to gentamicin, and 72 (52.4%) to cefepime. TEM was the main type of beta-lactamase among ESBL-producing K. pneumoniae, followed by SHV and CTX-M-1. Of the 30 isolates harboring CTX-M-producers, 53.3% co-produced TEM, 36.7% co-produced SHV, and the remaining isolates co-produced SHV and TEM. The data show that there is a high prevalence of ESBL-producing K. pneumoniae infections among pediatric inpatients in the region.

Declaration of interest: The authors declare that they have no competing interests. The authors alone are responsible for the content and writing of the manuscript.

The present project was funded by grants from the National Science & Technology Program during the Eleventh Five-Year Plan Period in China (2004BA720A09-02).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.