Disseminated cryptococcosis, invasive aspergillosis, and mucormycosis in a patient treated with alemtuzumab for chronic lymphocytic leukaemia

Aurélia Henn From the Infectious and Tropical Diseases Department, Paris, FranceCorrespondence[email protected]

Guillaume Mellon From the Infectious and Tropical Diseases Department, Paris, France

Benoît Henry From the Infectious and Tropical Diseases Department, Paris, France

Damien Roos-WeilHematology Department, Groupe Hospitalier Universitaire Pitié Salpêtrière, Université Pierre et Marie Curie–Paris 6, Paris, France

Stéphane Jauréguiberry From the Infectious and Tropical Diseases Department, Paris, France

Pierre MordantThoracic Surgery Department, Hôpital Européen Georges Pompidou, Université René Descartes–Paris 5, Paris, France

Arnaud FekkarMycology and Parasitology Laboratory, Groupe Hospitalier Universitaire Pitié Salpêtrière, Université Pierre et Marie Curie–Paris 6, Paris, France

Eric Caumes From the Infectious and Tropical Diseases Department, Paris, France

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Abstract

We report the case of a 42-y-old man treated with alemtuzumab for chronic lymphocytic leukaemia, who developed 3 successive deep fungal infections. Despite being treated with liposomal amphotericin B and 5-flucytosine for disseminated cryptococcosis, he developed pulmonary invasive aspergillosis, followed by pulmonary mucormycosis. Several deep fungal infections may occur in association in an immunocompromised host after treatment with alemtuzumab.

Keywords::

Declaration of interest: No funding; no conflict of interest.

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Disseminated cryptococcosis, invasive aspergillosis, and mucormycosis in a patient treated with alemtuzumab for chronic lymphocytic leukaemia

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Disseminated cryptococcosis, invasive aspergillosis, and mucormycosis in a patient treated with alemtuzumab for chronic lymphocytic leukaemia

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