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REVIEW ARTICLE

Novel approaches to tuberculosis prevention: DNA vaccines

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Pages 161-168 | Received 01 Oct 2013, Accepted 22 Nov 2013, Published online: 23 Jan 2014
 

Abstract

It is estimated that there are approximately eight million new cases of active tuberculosis (TB) worldwide annually. There is only 1 vaccine available for prevention: bacillus Calmette–Guérin (BCG). This has variable efficacy and is only protective for certain extrapulmonary TB cases in children, therefore new strategies for the creation of novel vaccines have emerged. One of the promising approaches is the DNA vaccine, used as a direct vaccination or as a prime-boost vaccine. This review describes the experimental data obtained during the design of DNA vaccines for TB.

Acknowledgements

We thank Cesar Rivas Santiago from Rutgers University for critical review and Daniel Cervantes- Villagrana for helping with the design of the figures.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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