Dramatic response to itraconazole in central nervous system aspergillosis complicating acute promyelocytic leukemia

Hong-Ling Peng From the Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, Hunan, P. R. China

Yi-Fang Yi From the Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, Hunan, P. R. China

Xiao-Hui Shen From the Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, Hunan, P. R. China

Ya-Fei Yin From the Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, Hunan, P. R. China

Guang-Sen Zhang From the Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, Hunan, P. R. ChinaCorrespondence[email protected]

Abstract

Fungal infection is a rare complication of acute leukemia, in which a combination of voriconazole and amphotericin B is a first-line regimen of treatment. Here administration of itraconazole plus caspofungin resulted in a dramatic response in a patient with acute promyelocytic leukemia (APL).

Declaration of interest: The authors report no conflicts of interest.

This work was supported by National Nature Science Fund (81200368) and The International Cooperation Project of Hunan Provincial Department of Science and Technology (No. 2011wk3043).

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Dramatic response to itraconazole in central nervous system aspergillosis complicating acute promyelocytic leukemia

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Dramatic response to itraconazole in central nervous system aspergillosis complicating acute promyelocytic leukemia

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