Prevention of CMV Infection by Screening for CMV Antibodies in Renal Allograft Recipients and Their Blood and Kidney Donors

Herold J. Metselaar Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Rutger J. Ploeg Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Anton M. Van Loon Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Harro T. Weiland Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Philip H. Rothbarth Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Leendert C. Paul Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Anneke Brand Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Ron Schaafsma Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Godefridus F. J. Hendriks Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Johannes Jeekel Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

Willem Weimar Departments of General Surgery, Internal Medicine I and Virology, University Hospital Rotterdam-Dijkzigt, Rotterdam; Departments of Surgery, Internal Medicine, Virology and Immunohaematology, University Hospital Leiden, Leiden; Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen; Eurotransplant Foundation, Leiden, The Netherlands

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Abstract

The influence of the cytomegalovirus (CMV) serostatus of blood and kidney donors on patient and graft survival was studied prospectively in 73 cadaveric renal graft recipients. Six out of 12 (50%) CMV seronegative recipients receiving a kidney from a CMV seropositive donor developed CMV disease, in contrast to none of 7 CMV seronegative donor/recipient combinations. Transmission of CMV with blood products to seronegative recipients was not observed in this study. A poor graft survival of 41% 3 years after transplantation was found in CMV seronegative recipients with CMV seropositive allograft donors, compared with an actuarial 3 year graft survival of 72% in the 7 CMV seronegative donor/recipient combinations. Six patients with graft failure had a CMV infection. This study, in accordance with other studies, suggests that selection of CMV seronegative renal allograft donors for CMV seronegative recipients will improve graft survival.

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Prevention of CMV Infection by Screening for CMV Antibodies in Renal Allograft Recipients and Their Blood and Kidney Donors

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Prevention of CMV Infection by Screening for CMV Antibodies in Renal Allograft Recipients and Their Blood and Kidney Donors

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