Respiratory Burst of Neutrophils Enhances in Hemorrhagic Fever with Renal Syndrome (HFRS)

Abstract

Respiratory burst of neutrophils was studied in 40 serologically verified patients with hemorrhagic fever with renal syndrome (HFRS) using luminol-dependent chemiluminescence (CL). Markedly increased CL has been demonstrated since the first days of the illness in all investigated patients. The level of CL was much enchanced during initial, oliguric, polyuric stages and convalescence. in a case of HFRS complicated by shock CL was approximately 100-fold higher than in healthy controls. It is suggested that neutrophils have an important role in the pathogenesis of HFRS.