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Abstract
Bleeding and severe thrombocytopenia developed in a 71–year-old man who had been receiving piperacillin 5 g intravenously every 8 h for 9 days for the the treatment of Pseudomonas aeruginosa septicemia. After piperacillin was discontinued, the platelet counts became normal. Rechallange was made with 2 g of piperacillin intravenously resulting in thrombocytopenia within 6 h of piperacillin administration. The platelet count normalized after 3 days when no further piperacillin was given.