Hemolysis and Autoantibodies to Triosephosphate Isomerase in a Patient with Acute Hepatitis A Virus Infection

Klaus Ritter Department of Medical Microbiology, Georg-August-University of Göttingen, Göttingen, Germany

Angela Uy Department of Medical Microbiology, Georg-August-University of Göttingen, Göttingen, Germany

Susanne Ritter Department of Medical Microbiology, Georg-August-University of Göttingen, Göttingen, Germany

Reiner Thomssen Department of Medical Microbiology, Georg-August-University of Göttingen, Göttingen, Germany

Abstract

Having returned from a holiday in Southeast Europe, a 30-year-old German woman developed acute hepatitis. Hepatitis A virus (HAV) infection was diagnosed serologically. During the course of the infection, hemolysis was found. IgM antibodies against triosephosphate isomerase (IgM anti-TPI) were detected in the patient's serum from the acute phase of the HAV infection. Affinity purified IgM anti-TPI from the serum reduced the enzyme activity in vitro and caused an increased⁵¹ Cr release from erythrocytes. IgM anti-TPI is assumed to be one of the causative agents of hemolysis in HAV infection.

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Hemolysis and Autoantibodies to Triosephosphate Isomerase in a Patient with Acute Hepatitis A Virus Infection

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Hemolysis and Autoantibodies to Triosephosphate Isomerase in a Patient with Acute Hepatitis A Virus Infection

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