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Abstract
1. In uraemic subjects, a diet furnishing around 40 g of protein per day can maintain nitrogen equilibrium. 17 g protein per day could not in the case where nitrogen balance was studied cause nitrogen equilibrium, and the nitrogen loss did not seem to diminish with time.
2. Extra calcium should be added to all uraemic subjects taking 40–50 g protein per day.
3. The addition of 10 g essential amino acids seemed to improve nitrogen balance in three out of four patients subjected to nitrogen balance studies.
4. Protein starvation with less than 20 g protein per day did not lower serum urea more than 40 g protein per day. The patients that improved in hospital on the protein-deficient diet improved as well on 40 g protein. Uraemic patients that progressively deteriorated on 40 g protein were not improved by 10 g protein per day but had to be subjected to dialysis. Patients with moderate to severe renal failure seem to benefit most, on the average, of a diet containing 40 g high-value protein and sufficient calories and calcium.