Sublimate Intoxication of Rat: A Pilot Scheme of Mortality and Renal Damage According to the Amount of Sublimate

Abstract

A series of rats was given different doses of sublimate as a one-time subcutaneous injection. the greatest polyuric effect without retention of urea, morphological renal damage, or mortality was obtained with 4 mg sublimate per kg body weight. Given 10 mg sublimate per kg body weight or more, all rats were rendered oliguric or anuric with extensive necrosis of the cells of the proximal tubules of the kidneys. Most of these rats died during the experimental period of 5 days. Support is given to the theory that sublimate intoxication affects both the glomerular filtration rate and the tubular reabsorption rate. Polyuria may thus be attributable to a discrepency between these two functions. Oliguria and anuria seem to be caused by a severe impairment of the glomerular function.