Thromboembolism During Estrogen Therapy of Prostatic Cancer: Report on Two Cases

Abstract

A deep venous thrombosis of the lower limb developed in two out of 42 prostatic cancer patients treated with estrogen who were followed up regularly. Based on this, 5% run the risk of thrombosis. In both cases, the development of thrombosis was preceded by a clear increase in serum total lipids, triglycerides, and certain coagulation factors. The increase in serum total lipids and triglycerides was clearly higher in the two thrombosis patients than in other patients in the investigation. The change in the coagulation factors in patients who developed thrombosis did not diverge from the general level, however. The relationship between these results and verified thrombosis in women taking oral contraceptives is discussed.