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Abstract
The renal artery circulation was occluded in one kidney in each of 9 dogs by the injection of autologous striated muscle tissue suspension into the renal artery. In 7 of the dogs an injection of 30% glucose was added. The injections were not followed by any spontaneous death or other unwanted effects. Functional, histological and micro-angiographical examinations showed that particularly the use of muscle tissue and glucose will result in massive thrombotic occlusion of the renal artery system with complete arrest of the renal artery blood flow and maximum necrosis of the kidney parenchyma. The tissue along the cortico-medullary border may partially survive, probably due to the existence of collateral vascular pathways. No blood pressure elevations were recorded.
The results suggest that the method of injections may be of value in the treatment of human cases of renal adenocarcinoma by improving the operability of large tumours and by reducing the tumour load.