Arteriovenous Fistulae in Rabbit Kidney Studied by Dye-Dilution Technique and by Angiography

Abstract

The effects of percutaneous punctures of kidneys of rabbits were studied by nephroangiography and by determination of renal blood flow using a dye-dilution technique. The punctures were made during the actual examination or up to 7 days earlier. At puncture small fistulae immediately were created, often only detectable by the dye-dilution technique. Slight arterial hypertension was registered in one rabbit with fistula, perhaps due to focal ischemia. Various vasoactive drugs were tested in order to increase the diagnostic accuracy at angiography and at the dye-dilution study. Only angiotensin proved to be of advantage. The combination of nephroangiography and blood flow determination using dye-dilution technique in man with fistulae, hemangiomas and tumours should be valuable, especially if angiotensin is employed.