Benign Prostatic Hypertrophy Treated with a Gestagen: A Double-Blind Clinical Trial with Randomized Allocation

Abstract

Forty-five patients with benign prostatic hypertrophy were included in a double-blind clinical trial using a synthetic gestagen compound—CIBA 31.458-Ba. No effect on prostatic obstruction could be detected. Regressive histological features were not found. It is concluded that double-blind techniques are indispensable in the evaluation of hormone treatment of benign prostatic hypertrophy since the symptoms may fluctuate spontaneously over long periods of time and a pronounced placebo effe:t is to be expected.

The authors want to thank Dr. H. Barlebo for performing the histological examination.