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Original Article

Human Histocompatibility Matching: II. Calculated Probability and Clinical Reality

, , , , , , , & show all
Pages 230-234 | Received 17 Aug 1973, Published online: 09 Jul 2009
 

Abstract

According to the rules of selecting suitable recipients for cadaver kidney transplants a high degree of HL-A compatibility is usually sought. This may lead to an uneven distribution of transplantations in the pool of waiting patients, favouring those who have a more common HL-A phenotype.

The probability for histocompatibility has been calculated for all of 5044 phenotypes (Högman et al., 1972). All patients who were registered in Scandiatrans-plant for kidney transplantation during a 6-month period were classified in retrospect according to this probability and followed up for at least 12 months.

High probability values were related to an early transplantation with a good HL-A match. Low probability figures were related to a high percentage of non-transplanted patients and a long waiting time before transplantation. Blood group A patients were transplanted twice as frequently as group O patients. We recommend that consideration be given to the calculated histocompatibility probability at each cadaver kidney transplantation.

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