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Abstract
The fate of 76 cadaveric kidneys removed from brain death donors with stable circulation has been analysed. Two kidneys were removed due to hyperacute rejection. Fifteen recipients needed postoperative dialysis, and 4 of these died within 16 days post-transplant without kidney function. Among 59 patients with immediate graft function, 1 patient died in the same period.
Donor treatment with heparin and chlorpromazine before nephrectomy resulted in immediate function of all kidneys, indicating that renal vasospasm may be responsible for the postoperative anuria. Graft survival at 6 months was 60% and only 3 of 42 patients had serum creatinine of 2.0 mg/100 ml or more.
It is concluded that the problem of primary nonfunction of cadaveric kidneys can be eliminated with this type of donor, and that the quality of kidney function will improve.