The Determination of Fibrinolytic Degradation Products in Concentrated Urine After Renal Transplantation

M. EkbergRenal Unit, Department of Internal Medicine, Department of Surgery and the Coagulation Laboratory, Malmö Allmänna Sjukhus, University of Lund, 21401 Malmö, Sweden

S.-E. BergentzRenal Unit, Department of Internal Medicine, Department of Surgery and the Coagulation Laboratory, Malmö Allmänna Sjukhus, University of Lund, 21401 Malmö, Sweden

U. HednerRenal Unit, Department of Internal Medicine, Department of Surgery and the Coagulation Laboratory, Malmö Allmänna Sjukhus, University of Lund, 21401 Malmö, Sweden

I. M. NilssonRenal Unit, Department of Internal Medicine, Department of Surgery and the Coagulation Laboratory, Malmö Allmänna Sjukhus, University of Lund, 21401 Malmö, Sweden

Abstract

Fibrin/fibrinogen degradation products (FDP) were determined in concentrated as well as unconcentrated urine in 29 patients undergoing renal transplantation. When determined in unconcentrated urine, FDP was found for 3-4 weeks after an uneventful transplantation, compared with 12 weeks when determined in concentrated urine. After acute rejection episodes FDP was found in unconcentrated urine, but remained in the concentrated urine for 8 weeks longer when concentrated urine was used for determination. In early chronic rejection and glomerulonephritis, FDP appeared as a sign of glomerular lesion in concentrated urine before it was found in unconcentrated urine. It was concluded that the presence of FDP in concentrated urine is a diagnostic tool of value particular in detecting early glomerular lesions caused by chronic rejection or glomerulonephritis.

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The Determination of Fibrinolytic Degradation Products in Concentrated Urine After Renal Transplantation

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The Determination of Fibrinolytic Degradation Products in Concentrated Urine After Renal Transplantation

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