The Effect of Chlorpromazine and Heparin Pretreatment on Kidney Viability and Function After Warm Ischaemic Damage

Abstract

The influence of chlorpromazine and heparin pretreatment on kidney function and histology has been investigated in rabbit kidneys damaged by warm ischaemia. Three experimental groups were investigated. One in which animals were pretreated with heparin, one group pretreated with heparin and chlorpromazine, and one group without pretreatment. The left renal artery was temporarily clamped for 3 hours and the kidneys recirculated. After 2-3 weeks a delayed contralateral nephrectomy was made, and after another 2-3 weeks all kidneys were studied histologically. Kidney function was measured by determination of serum-creatinine. The experiments showed, that all animals survived with impaired renal function. Pretreatment with chlorpromazine and heparin did not affect the final results. Severity of the ischaemic damage, histologically evaluated was the same in all groups.