A Morphological Study on the Effect of Cyproterone Acetate on Human Prostatic Carcinoma

K. J. TveterDepartment of Surgery, Section of Urology, and the Institute of Pathological Anatomy, the National Hospital of Norway, and the Department of Surgery, the University Hospital of Akershus, Oslo, Norway

A. AttramadaDepartment of Surgery, Section of Urology, and the Institute of Pathological Anatomy, the National Hospital of Norway, and the Department of Surgery, the University Hospital of Akershus, Oslo, Norway

R. HannestadDepartment of Surgery, Section of Urology, and the Institute of Pathological Anatomy, the National Hospital of Norway, and the Department of Surgery, the University Hospital of Akershus, Oslo, Norway

B. OtnesDepartment of Surgery, Section of Urology, and the Institute of Pathological Anatomy, the National Hospital of Norway, and the Department of Surgery, the University Hospital of Akershus, Oslo, Norway

Abstract

Sixteen patients with prostatic carcinoma were treated with 200 mg of Cyproterone acetate daily. No other kind of hormonal treatment was given. Transrectal biopsies of the prostate were taken before the treatment was started, and at regular intervals afterwards. The treatment period lasted from 3 to 16 months, with an average of 9 months. A thorough examination of multiple sections from all specimens revealed no convincing signs of cellular involution. The study has demonstrated no specific or significant atrophic changes following Cyproterone acetate therapy. Some possible explanations regarding the effect of Cyproterone acetate on human malignant prostatic tissue are discussed.

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A Morphological Study on the Effect of Cyproterone Acetate on Human Prostatic Carcinoma

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A Morphological Study on the Effect of Cyproterone Acetate on Human Prostatic Carcinoma

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