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Scandinavian Journal of Urology and Nephrology Volume 14, 1980 - Issue 3
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Original Article

Sulphonamide as Hemolysis-Promoting Factor in Uremia

S. G. EklundDepartments of Medicine and Clinical Chemistry, Karolinska Sjukhuset, Stockholm, Sweden
,
S. V. JohanssonDepartments of Medicine and Clinical Chemistry, Karolinska Sjukhuset, Stockholm, Sweden
,
L. E. LinsDepartments of Medicine and Clinical Chemistry, Karolinska Sjukhuset, Stockholm, Sweden
&
O. StrandbergDepartments of Medicine and Clinical Chemistry, Karolinska Sjukhuset, Stockholm, Sweden
Pages 275-277 | Received 01 Apr 1979, Published online: 15 Feb 2010
 
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Abstract

Nine out of 39 uremic patients treated with sulphonamides because of urinary tract infection developed hemolysis. Heinz-bodies were seen in all cases. In uremic patients a defect of the HMP metabolic pathway renders these patients susceptible to hemolysis when treated with oxidant drugs.

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