Neuromuscular Transmission in the Corpus-Fundus of the Urinary Bladder

Abstract

In muscle strips from the corpus-fundus of the cat bladder the intramural nervous system was activated by field stimulation. The resulting muscle contraction could not be inhibited by atropine, phentolamine or quinidine. These drugs enhanced the response. Tet-rodotoxin, methysergide, cyproheptadine and indometha-cin blocked the field-stimulation response in a dose dependent manner. The interpretation of these results with references to transmission at the neuromuscular junction of the bladder is discussed.