Uninhibited Neurogenic Bladder Treated with Prazosin

Abstract

The effect of the new alpha-adrenoreceptor blocking agent prazosin on hypermotility of the urinary bladder was investigated, using controlled cystometry in neurological patients with normal bladder or with uninhibited neurogenic bladder. In short-term administration of prazosin, the bladder capacity was markedly increased and the uninhibited detrusor contraction was diminished. Long-term treatment with prazosin gave subjectively improved micturition in patients with detrusor-sphincter dyssynergia. The cystometrograms then showed less pronounced improvement than in short-term medication. Prazosin offers a valuable supplement to the existing choice of therapeutic agents for uninhibited neurogenic bladder. Side effects of the drug were few.