Continued Experimental Study on the Pathogenesis of Sporadic Bacteriuria in the Rat. II

Abstract

The previously described experimental model implying ligature of the left ureter in the rat has been used in continued experiments. The present experiments intended to saturate the reticuloendothelial system with dead E. coli, and thereby produce a possible increase in the seeding of bacteria into the experimental locus minoris resistentiae. The results indicate that usage of organic material as E. coli may also stimulate the RES system. Most probably, the incidence of experimental infections in the left ureter is influenced upon by 2 main variables: the size of the experimental bacteremia and the current state of host defence mechanisms.