Relation Between Hypercalciuria and Vitamin D₃-Status in Patients with Urolithiasis

Abstract

Patients with urolithiasis were divided into two groups, one (n = 38) with a urinary excretion of calcium exceeding 6.0 mmol/24 h and one (n = 32) with a calcium excretion lower than 6.1 mmol/24 h. The group of patients with a high urinary excretion of calcium had a significantly higher level of 25-hydroxy vitamin D₃ (26.2±1.6 ng/ml) than had the group of patients with a normal urinary excretion of calcium (17.6±0.9 ng/ml) (p<0.001). A highly specific and accurate method, based on isotope dilution—mass spectrometry was used in the assay of 25-hydroxy vitamin D₃. There was no over-all correlation between level of 25-hydroxy vitamin D₃ and serum level of calcium (r = −0.1). The results are in accordance with the contention that the vitamin D₃-status might be of some importance for the development of hypercalciuria in these patients.