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Original Article

Effects of Chronic Uremia on Bone

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Pages 275-278 | Received 12 Apr 1981, Published online: 15 Feb 2010
 

Abstract

Iliac crest bone biopsies in patients with chronic renal failure with severely disturbed renal function were measured with regard to osteoclast activity and active and inactive osteoid. In none of the 21 patients had hemodialysis been applied. In uremia cases, as earlier demonstrated in hemodialysis cases, the alkaline phosphatase and the parathyroid hormone activity were the best variables for prediction of bone complications. However, none of the laboratory variables or all taken together could predict the type of bone changes. The osteoclast activity was less than in hemodialysis cases indicating that secondary hyperparathyroidism may be less important in the non-hemodialysed cases.

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