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Abstract
The circulatory effects of intravenously administered indomethacin, a potent prostaglandin synthesis inhibitor (0.8 mg/kg bw) were investigated in pigs with unilateral ureteral obstruction. The drug induced a marked but transient increase in systemic arterial pressure (+53%, p<0.02) and pulmonary arterial (+81%, p<0.02) pressure without any changes in left or right sided filling pressures, cardiac output or heart rate. Coronary blood flow remained unchanged and renal venous blood flow decreased (−26%, p<0.02). Renal pelvic pressure decreased (−20%, p<0.02). Thus systemic (SVR), pulmonary (PVR) and coronary vascular resistance (CVR) and renal vascular resistance (RVR) on the obstructed side increased (SVR+73%, p<0.02; PVR+140%, p<0.02; CVR+53%, p<0.02 and RVR+107%, p<0.02 respectively).
Even if one takes into consideration other factors than ureteral obstruction contributing to these reactions, e.g. low volume load, anaesthesia, surgical trauma and species differences, care is adviced in treating patients with coronary artery disease or obstructive lung disease with indomethacin.