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Abstract
In a prospective randomized study of 96 patients, the effect of a short antibiotic course given after transurethral prostatic resection was analysed, Cefotaxime (1 g. i.m. every 12 hours to a total of 3 g) was given to 47 patients with the first doses when the postoperative catheter was removed while 49 were assigned to a control group without antibiotic. The frequency of bacteriuria was 48% preoperatively in the cefotaxime group and 33% six weeks postoperatively. In the control group the corresponding figures were 63% and 50% (p>0.1). There were two cases of septicemia in each group immediately post-operatively whereas upper urinary tract infection developed in five patients in the control group and one patient in the cefotaxime group (p>0.1). The total number of infectious and non-infectious complications was significantly greater in the control group (22) compared to the cefotaxime group (12) (p<0.05). The patients receiving the antibiotic remained a shorter time in hospital as compared to the controls. Bacteriological analysis showed a good in vitro effect of cefotaxime on isolated bacteria.