Deoxythymidine Kinase, a Possible Marker for Monitoring Activity of Cytomegalovirus Infection After Renal Transplantation

A. Larson Department of Urology, University Hospital, Uppsala

L. Frödin Department of Urology, University Hospital, Uppsala

G. Tufveson Department of Urology, University Hospital, Uppsala

E. Larsson Department of Pathology, University Hospital, Uppsala

C. F. R. Källande Department of Medical Virology, Biomedical Center, University of Uppsala, Uppsala, Sweden

J. S Gronowitz Department of Medical Virology, Biomedical Center, University of Uppsala, Uppsala, Sweden

Abstract

Measurement of deoxythymidine kinase activity (S-TK) in serum is used as a marker for cytomegalovirus (CMV) infection following transplant surgery. A case is presented where a kidney transplant patient suffered a fatal CMV infection. The new antiviral drug Foscarnet® was used to treat the infection. Retrospective analysis of S-TK showed a good correlation with the course of the disease, its treatment, recurrence and final outcome.

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Deoxythymidine Kinase, a Possible Marker for Monitoring Activity of Cytomegalovirus Infection After Renal Transplantation

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Deoxythymidine Kinase, a Possible Marker for Monitoring Activity of Cytomegalovirus Infection After Renal Transplantation

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