176
Views
11
CrossRef citations to date
0
Altmetric
Urology

Effect of endocrine treatment on voiding and prostate size in men with prostate cancer: A long-term prospective study

, , &
Pages 37-43 | Received 23 Apr 2011, Accepted 02 Oct 2011, Published online: 12 Dec 2011
 

Abstract

Objective. The aim of this study was to assess and quantify changes in voiding parameters and prostate size in men with prostate cancer from before the start of endocrine treatment and during long-term follow-up. Material and methods. Seventy-seven patients were recruited from three clinics and followed prospectively until death, clinical deterioration making the patient unfit for participation, or the end of the study. Median age was 74 (range 54–85) years, and the median follow-up was 18 (3–90) months. Parameters and endpoints were total score on the Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire, maximum flow rate, postvoid residual volume, frequency and voided volume, and prostate volume on transrectal ultrasonography. Results. All parameters improved significantly in the range of median 13–50% within the first 12 months. The greater part of the effect occurred during the first month, and thereafter the improvement rate slowed down. Intervention for local progression was estimated on Kaplan–Meier analysis to be about 20% after 4 years. 73% had a defined prostate-specific antigen nadir after a median of 6 (1–60) months with scheduled assessments up to 72 months after the nadir. All parameters were improved before the nadir and the improvement remained during biochemical progression except for the very latest visits where few patients contributed to the analyses. Conclusions. Androgen deprivation therapy improved lower urinary tract symptoms, objective voiding parameters and prostate volume in patients with prostate cancer who were not candidates for curative treatment. The improvement was significant within the first month and clinically relevant. Despite biochemical progression the effect may last for years, and only a minority will need intervention for local progression.

Acknowledgements

MD Niels Skovgaard Head of Department of Radiology, Glostrup Hospital, is greatly acknowledged for prostate volume measurements, and Doctor of Medical Science Kári J. Mikines is thanked for the Kaplan–Meier analysis.

Declaration of interest: No funding or other financial support was received for this work.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.