Desmopressin: A new Principle for Symptomatic Treatment of Urgency and Incontinence in Patients with Multiple Sclerosis

Abstract

Thirteen patients with advanced multiple sclerosis and urge urinary incontinence were treated with desmopressin–a synthetic analogue of antidiuretic hormone in a double-blind cross-over study. The micturition frequency decreased significantly (p<0.05). Less leakage was considered valuable for daily life. Peroral medication was favourable in these patients with muscular dysfunction. Side-effects were few.

Keywords:

• urge incontinence
• neurogenic bladder dysfunction
• desmopressin.