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Original Article

The Influence of β-Adrenoceptor and Muscarinic Receptor Agonists and Antagonists on the Static Urethral Closure Function in Healthy Females

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Pages 31-38 | Received 20 Jan 1992, Accepted 02 Apr 1992, Published online: 15 Feb 2010
 

Abstract

The effects of terbutaline, propranolol, carbachol, and atropine on the static urethral closure function were investigated in 20 healthy women. Terbutaline caused a statistically reduction of the urethral pressure in the high pressure zone, but not at the bladder neck or in the distal urethra. The other drugs caused no significant pressure changes. None of the drugs used produced significant changes in the static viscoelastic properties, elastance, and hysteresis of the resting urethra. It is suggested that terbutaline partly reduces intraurethral pressure by reducing muscular tone in the rhabdosphincter and pelvic floor.

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