Urinary Excretion Patterns of Pseudouridine and β-Aminoisobutyric Acid in Patients with Tumours of the Urinary Bladder

Abstract

The preoperative and postoperative values of urinary pseudouridine: creatinine (Φ:C) and β-aminoisobutyric acid: creatinine (βAIB:C) were estimated, in 192 patients with urethelial tumours of the bladder, 92 of whom had not previously been diagnosed. Urinary Φ:C ratio correlated with the grade of tumour cell dysplasia (being highest in dysplasia grade 3), and to a lesser extent with the clinical stage. The treatment had no major influence on the excretion ratios. Decreased ratios, or those within the reference range, were associated with a better prognosis than increased ratios, and if both were increased at the same time the risk for progression of the disease was high. The biological tumour markers pseudouridine and β-aminoisobutyric acid may be helpful in the diagnosis of tumours in the upper urinary tract, and in the follow-up of patients with tumours of the bladder.

Keywords:

• pseudouridine
• β-aminoisobutyric acid
• tumour markers
• urinary bladder tumours