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Original Article

Crystal Adherence to Rat Bladder Epithelium after Long-Term E. coli Infection

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Pages 71-74 | Received 30 Nov 1991, Accepted 04 Jan 1992, Published online: 15 Feb 2010
 

Abstract

The normal urothelium is covered by a mucous coat which acts as an unspecific barrier against the adhesion of bacteria, cancer cells and crystals. Acute bacterial infections cause disruptions of the mucous coat and impairment of its anti-adherent property. The effect of long-term infection is, however, not known. Live E. coli were inoculated into rat urinary bladders and a persisting infection was obtained by creating a small bladder diverticulum. After 2, 10 and 21 days a crystal adhesion assay showed a twofold increased adherence to the urinary bladder in the infected rats compared to control (p<0.001). One possible explanation could be an injury to the mucous coat.

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