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Original Article

Crypt Cell Thymidine Incorporation in Ileal Urinary Pouch

Preliminary Report

, , &
Pages 147-151 | Received 09 Jul 1993, Accepted 29 Jul 1993, Published online: 15 Feb 2010
 

Abstract

This is a brief communication about mucosal change in ileal urinary reservoirs, the earliest reported observations to date. Previous authors described early villous atrophy and crypt elongation, late panmucosal atrophy and metaplasia. Crypt cell proliferation should be a forerunner of these events and therefore warrants quantitative measurement. We studied continent pouches in dogs on postoperative days 42 and 43 using in vivo tritiated thymidine incorporation into crypt cell DNA, a novel application of autoradiography for urinary reservoirs. Adjacent normal ileum provided the internal control. Increased crypt cell thymidine incorporation was confirmed at this early time.

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